Submit Manuscript  

Article Details


Anti-annexin A5, Antiphosphatidylinositol Antibodies, and Haematological Parameters in Preeclampsia Patients: A Case-Control Study

[ Vol. 17 , Issue. 1 ]

Author(s):

Wan Haslindawani Wan Mahmood*, Md Asiful Islam, Mimi Azreen Abdullah, Noor Haslina Mohd Noor, Indhira Subbiah, Ahmad Amir Ismail, Mohd Haslan Hassan and Wan Zaidah Abdullah   Pages 74 - 78 ( 5 )

Abstract:


Background: Prevalence and the risk of common antiphospholipid antibodies (aPLs), such as lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (β2-GPI) antibodies, in preeclampsia is a matter of debate. Recently, interests have expanded in evaluating the risks of presenting non-classic aPLs in preeclampsia patients.

Objective: The objective of this case-control study was to evaluate some hematological parameters besides assessing the presence of anti-annexin A5 and anti phosphatidylinositol (aPI) antibodies in preeclampsia patients compared to non-preeclampsia subjects.

Methods: From two hospitals in Malaysia, a total of 84 subjects were recruited in this case-control study, including 42 preeclampsia and 42 age-matched non-preeclampsia subjects. Some hematological parameters [i.e., hemoglobin, total white blood cell, platelet, prothrombin time, and activated partial thromboplastin time (APTT)] were assessed besides screening for anti-annexin A5 and aPI antibodies.

Results: Among the hematological parameters, APTT was significantly high in mild preeclampsia when compared to severe preeclampsia subjects (p=0.007). IgG anti-annexin A5 antibody was detected in a single preeclampsia subject only (2.4%) and none in non-preeclampsia subjects.

Conclusion: Because of the low prevalence, non-classic aPLs should not be considered as a risk factor in developing preeclampsia and it is not justifiable to consider them as a routine assay in pregnant women.

Keywords:

Preeclampsia, hematological, activated partial thromboplastin time, antiphospholipid, anti-annexin A5, antiphosphatidylinositol.

Affiliation:

Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Department of Pathology, Hospital Sultanah Aminah, Johor Bahru, Johor, Department of Obstetrics and Gynaecology, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Department of Obstetrics and Gynaecology, Hospital Sultan Ismail, Johor Bahru, Johor, Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan

Graphical Abstract:



Read Full-Text article