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The Role of Natural Killer Cells and Mast Cells in Female Infertility and Associated Treatment Outcomes

[ Vol. 16 , Issue. 2 ]


Nahid Lorzadeh* and Nastaran Kazemirad   Pages 102 - 106 ( 5 )


Introduction: One of the identified causes of infertility has been related to the inability to regulate immunological tolerance of the maternal immune system against the developing fetus, thereby inhibiting the process of implantation. Various immune cells have been identified to contribute to the concept of un-regulated immunological tolerance, such as mast cells (MCs) and natural killer cells (NK). There are available evidences that MC play a role in the pathogenesis of infertility diseases like endometriosis and NK in specific infertility disease.

Objective: Presently, there are studies to formulate and develop immunosuppressive drugs in order to suppress or inhibit the process of immune rejection caused by maternal immune cells. In addition, there have been reports regarding the use of steroids for the treatment of miscarriage that can inhibit the activity of most immune cells.

Conclusion: This review is to give a comprehensive mini-review on the role of immune cells, especially mast cells and NK cells in developing novel infertility treatment.


Infertility, immune cells, immunosuppressive drug, implantation, natural killer cells, mast cells.


Department Obstetrics and Gynecology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Student Research Committee, Faculty of Medicine, Tehran University of Medical Sciences, Tehran

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